Open Access Publishing: December 04, 2015 Comparative Study of Binding Activity curcumin and Didemethylated curcumin and selenite acid: Diene, Hydrogen bond and acid-base interaction Jiahn-Haur liao, pure spirit Chen Tzu-hua Wu Wei-ting Chen Hou-yun Lu Yi-hsuan Wang Shao-min Hsu Yi-shiang huang Huang Zih-you Yu-ching Lin, Qingming Festival, Huang Furong,

In this report, the in vitro relative function (CCM) of curcumin and didemethylated curcumin (DCCM) were used to detect the activity of SELENite-induced lens protein polymerization and isothermal titration calorimetry (ITC) DCCM was stronger than CCM

By molecular orbital calculation of CCM/SeO32 and DCCM/SeO32 complexes of conformation, the optimization results show that selenious acid anion through between selenite and CCM CCM surrounding the h key, this phenomenon also by IR and NMR were studied for DCCM, is the main driving force of the form, acid-base adduct with selenite illustrate DCCM phenolic hydroxyl group was the mainspring of forming DCCM the conformation

With CCM or DCCM selenite complexes formation mechanism explains why in reducing the toxicity of selenite, prevent the lens protein aggregation induced by selenite, DCCM activity is greater than the CCM of open access publishing: comparative study in December 2015, 04 binding activity of curcumin and Didemethylated curcumin and selenite: hydrogen bonding interaction with acid-base Jiahn - Haur liao Ming yi Chen Tzu - Hua Wu Wei - Ting Chen Shou - Yun Lu

Yi-hsuan Wang Shao-pin Wang Yen-min Hsu Yi-shiang Huang Huang Zih-You Yu-Ching Lin, Qingming Festival, Huang Furong,

In this report, the in vitro relative function (CCM) of curcumin and didemethylated curcumin (DCCM) were used to measure turbidiene in preventing induced lens protein polymerization and isothermal titration calorimetry (ITC). The activity of DCCM was stronger than that of CCM

The CCM is a plant active ingredient in turmeric rhizomes 23, and its derivatives to take off the methoxy curcumin double off methoxy curcumin removal ability and interact with a variety of free radicals in 24 recently, health characteristics of curcumin (nerve protection chemistry and cancer prevention) gets more and more attention, including the characteristics of the body resistance to cataracts, 26 and 27, 28, 29 31 before 30, curcumin has been observed by various chemical insulation resistance to protect the lens from 30,32,33 cataracts occur

Most of these features associated with the antioxidant activity of curcumin experiments have shown that curcumin can adjust partner protein expression of retina another experiments have shown that curcumin cataract caused by ionizing radiation protective 35 by changing the structure of curcumin, enhance its resistance to the activity of cataract in the use of CCM as a kind of effective human before cataract drug resistance, you need to do a lot of research before we study astaxanthin and pyrazole Renault through interaction with selenite improve selenite induced cataract 19, 21

It has been reported that CCM prevents or reduces selenium-induced oxidative stress, thereby inhibiting lens opacity 28 The mechanism by which selenite induces cataract formation has been extensively studied 38 However, it is not clear how CCM interacts with selenite

In this study, the anti-cataract chemical properties of CCM were further studied by FT-IR ITC NMR and computational analysis, although derivatives of salicylic acid and benzoxygenin 36 can attenuate the formation of cataracts in vitro.

However, the role of demethylated compounds in anti-cataract is unclear and compared with CCM, dimethylated curcumin was determined by a parallel method (DCCM, CID 5469425)