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Hubei Minsheng biomedical Co., Ltd

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123 Jingmenshan Avenue, Honghuatao Town, Yidu City, Hubei Province, China

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Website: en.minshengchem.com

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6-302 Dafan Dadao, Yichang City, Hubei Province, China

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Chinas first annual output of 100 tons of DHEA new process production line into production

2014-08-18 00:00:00
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China's first annual output of 100 tons of DHEA new process production line into production


In order to reduce the cost and solve the problem of environmental pollution in the process of pharmaceutical, interdisciplinary science and technology higher institute of Shanghai engineering research center for molecular therapy and drug discovery Shang Jie and what professor team after more than three years of exploration, has realized the key intermediate of steroidal drugs DHEA (to) hydrogen therapy synthetic new technology difficulties of breakthrough, in the domestic first developed a new technology of production value of DHEA, built in the factory at the first annual output of 100 tons of DHEA a new process line has been built and put into production smoothly

China's first new process production line with an annual output of 100 tons of DHEA was put into operation. The original process cost is high and the steroid hormone drugs are the second category of drugs after antibiotics, which are widely used in the treatment of rheumatoid arthritis, bronchial asthma and skin diseases.

Can also be used for contraception fetus alleviate symptoms of menopause women to lose weight, etc. At present, the production of steroid drug varieties has reached more than 300 kinds of DHEA is the synthesis of mifepristone flexor screw ketone acetate abiraterone acetate optimal force department special key intermediates of steroid hormone drugs, its raw material relies heavily on derived from natural products of yam diosgenin double enol ketone acetate is the production of yam diosgenin powers in China, the annual output over 4000 tons, about 90% of global output, however, the environmental pollution problem has plagued the industry yam diosgenin by huangshan drugs (also called it, or

Turmeric herb) extraction and huangshan mountain medicine not only production cycle need three years or so, and in the process of extraction of yam diosgenin will generate serious environmental pollution, every production will produce hundreds of tons of tons yam diosgenin wastewater in addition, each 1 of oxidative degradation, yam diosgenin will produce 4 tons of chromium pollution at the same time, due to the national related department to drug firms industry the requirement of environmental protection is increasing, yam diosgenin price has been soaring, the production and development of DHEA severely restrict not only threaten the survival of some steroid drug firms, and it will affect China's status as a global leading suppliers of steroid apis

From laboratory to production line was built three years and the process of use from natural yam diosgenin double enol ketone acetate is different, the new process is made of raw material for soybean oil by-products after fermentation generated 4 - androstenedione (4 - AD), not only rich raw material source comes easily to the cost is only about half of the double enol ketone acetate, and avoid the chromium pollution in 2010, professor Shang Jie and what research combined with the enterprise bear the major national science and technology major special corpus of mifepristone API drugs oriented technical transformation

The formulation of replacing diosgenin with soybean oil by-product is not new. However, these are mostly the results of laboratory research, which cannot meet the actual production requirements in terms of product quality and cost control

Shang Jie, says professor for the research efforts of the laboratories used in real production, professor Shang Jie and what lead the team to relevant personnel in the laboratory and production workshop after countless times of travel and exploration, and finally successfully developed new technology of DHEA synthesis, and in the factory built China's first production 100 tons/year of DHEA (center) and new process line Shang Jie professor team members working in the factory to check production line is opening up new ways of steroidal drugs raw material diversification

New technology successfully using cheap soybean oil by-products, use of biological transformation and the combination of chemical synthesis method, instead of the high cost of raw materials, high pollution has significant economic benefits not only for our country steroidal drugs raw materials of diversified open new avenues of research, and for the transformation and upgrading of related steroid drug companies played a crucial role as we have learned, the domestic first production 100 tons/year of DHEA new process line has been completed and put into production in July in zhejiang smoothly, the annual output value will be more than 200 million yuan of the production line

Another production 300 tons/year of DHEA new process line is currently under construction, next year is expected to be built and put into production, the study is a professor in our university as a host of major national science and technology major special drugs oriented five-year plan project funding and interdisciplinary higher institute of science and technology in 985 and Shanghai engineering research center for molecular therapy and drug discovery platform under the support of, performed by professor Shang Jie and what team, is our school and enterprise cooperative innovation of new achievements


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